NAD+ is a critical coenzyme that supports energy metabolism, DNA repair, and cellular health. See research studies in "NAD+ and NR Research Studies"
However, NAD+ levels decline with age, so we need NAD+ supplements for healthy aging. The main ways to supplement NAD+ in the human body are as follows:
- Salvage Pathway: which is the main pathway, involving Nicotinamide Riboside (NR), Nicotinamide (NAM), and Nicotinamide Mononucleotide (NMN).
- Preiss-Handler Pathway: This pathway mainly involves Nicotinic Acid (NA).There are various ways to supplement NAD+, and there are many NAD+ supplements available in the market.
So, how do we choose the right one? Based on extensive scientific research and experiments, Selerb team chose Nicotinamide Riboside (NR) as the NAD+ supplement. Why?
- First, studies show that NR has no significant side effects on the human body and is safe for long-term use.
- Second, the molecular weight of NR is 256, which is smaller than that of NMN at 334, and NAD+ at 663. This means NR can enter cells more effectively and produce effects.
- Third, high doses of nicotinic acid (NA) may cause side effects called "niacin flush," which is a burning, tingling sensation in the face and chest, and red or flushed skin. So we do not recomend nicotinic acid(NA).
- And considering that, the FDA concluded that NMN is excluded from dietary supplement products in 2022.
- So, NMN and NA are not our choice.
- Also, NR has become the preferred NAD+ precursor for major brands, further validating its reliability and efficacy.
This is why Aresify chose NR as the core ingredient to supplement NAD+.
More importantly, Aresify’s synergistic formula also includes Q10 and Niacinamide to enhance healthy aging effects.
This proprietary blend formula is called NADGENIE™, which is the pioneering third-generation NAD+ technology.
These ingredients work synergistically with NR to deliver better healthy aging effects. They promote healthier skin, provide antioxidant protection, and enhance cellular energy and metabolism.